the association of childhood asthma and helicobacter pylori infection in sardinia

background: it has been suggested that helicobacter pylori infection might reduce the risk of atopic conditions, such as asthma, in childhood. this risk reduction could relate to the “hygiene hypothesis” which proposes an association between childhood exposure to microbes and risk of atopy. objectives: to examine the association between hp infection and childhood acquired asthma in sardinia. patients and methods: children from northern sardinia who were between the ages of 10 months to 6 years and were screened for hp infection in 1994-1995 using igg serology, were asked in 2012, whether they had developed asthma and/or allergic disease in pediatric age, using the global initiative on asthma guidelines questionnaire. results: a total of 64 children participated in the study. the sero-positivity for hp infection was 14.1%. eleven (17.2%) children had a confirmed diagnosis of asthma with onset before the age of 5 years, 85.9% were hp negative and 14.1% hp positive. eight children of the 53 without asthma were hp positive (15%) compare to one children positive for the infection of the 11 patients (0.09%) with asthma (8/53 vs. 1/11; p = 0.6). the majority of children (73%) were from urban areas and 43.8% had a family history of asthma or allergies. multiple logistic regression analysis was not able to find a studied variable, including hp infection, significantly associated with pediatric asthma. conclusions: our results speak against hp infection itself playing a role to protect from the risk to develop childhood asthma although household hygiene was not directly assessed.